AUTHOR=Barandouzi Zahra Amirkhanzadeh , Starkweather Angela R. , Henderson Wendy A. , Gyamfi Adwoa , Cong Xiaomei S. 

TITLE=Altered Composition of Gut Microbiota in Depression: A Systematic Review

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00541

DOI=10.3389/fpsyt.2020.00541

ISSN=1664-0640

ABSTRACT=<p>Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 and June 2019, was reviewed. The key words included gastrointestinal microbiome, gut microbiome, microbiota, depression, depressive symptoms, and depressive disorder. The systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Nine articles met the eligibility criteria. Disparities in α-diversity and β-diversity of the microbiota existed in people with depression compared to healthy controls. At the phylum level, there were inconsistencies in the abundance of <italic>Firmicutes</italic>, <italic>Bacteroidetes</italic>, <italic>and Proteobacteria</italic>. However, high abundance in <italic>Actinobacteria</italic> and <italic>Fusobacteria</italic> phyla were observed in people with depression. On the family level, high abundance of <italic>Actinomycineae</italic>, <italic>Coriobacterineae</italic>, <italic>Bifidobacteriaceae</italic>, <italic>Clostridiales incertae sedis XI</italic>, <italic>Porphyromonadaceae</italic>, <italic>Clostridiaceae</italic>, <italic>Lactobacillaceae</italic>, <italic>Streptococcaceae</italic>, <italic>Eubacteriaceae</italic>, <italic>Thermoanaerobacteriaceae</italic>, <italic>Fusobacteriaceae</italic>, <italic>Nocardiaceae</italic>, <italic>Streptomycetaceae</italic>, <italic>and</italic> low abundance of <italic>Veillonellaceae</italic>, <italic>Prevotellaceae</italic>, <italic>Bacteroidaceae</italic>, <italic>Sutterellaceae</italic>, <italic>Oscillospiraceae</italic>, <italic>Marniabilaceae</italic>, and <italic>Chitinophagaceae</italic> were observed in people with depression. On the genus level, high abundance of <italic>Oscillibacter</italic>, <italic>Blautia</italic>, <italic>Holdemania</italic>, <italic>Clostridium XIX</italic>, <italic>Anaerostipes</italic>, <italic>Anaerofilum</italic>, <italic>Streptococcus</italic>, <italic>Gelria</italic>, <italic>Turicibacter</italic>, <italic>Parabacteroides</italic>, <italic>Eggerthella</italic>, <italic>Klebsiella</italic>, <italic>Paraprevotella</italic>, <italic>Veillonella</italic>, <italic>Clostridium IV</italic>, <italic>Erysipelotrichaceae incertae sedis</italic>, <italic>Eubacterium</italic>, <italic>Parvimonas</italic>, <italic>Desulfovibrio</italic>, <italic>Parasutterella</italic>, <italic>Actinomyces</italic>, <italic>Asaccharobacter</italic>, <italic>Atopobium</italic>, <italic>Olsenella</italic> and low abundance of <italic>Coprococcus</italic>, <italic>Lactobacillus</italic>, <italic>Escherichia/Shigella</italic>, <italic>Clostridium XlVa</italic>, <italic>Dialister</italic>, <italic>Howardella</italic>, <italic>Pyramidobacter</italic>, and <italic>Sutterella</italic> were found in people with depression. Alteration of gut microbiome patterns was evident in people with depression. Further evidence is warranted to allow for the translation of microbiome findings toward innovative clinical strategies that may improve treatment outcomes in people with depression.</p>