AUTHOR=Wilkowska Alina , Szałach Łukasz , Słupski Jakub , Wielewicka Aleksandra , Czarnota Małgorzata , Gałuszko-Węgielnik Maria , Wiglusz Mariusz S. , Cubała Wiesław J. 

TITLE=Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review

JOURNAL=Frontiers in Psychiatry

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00516

DOI=10.3389/fpsyt.2020.00516

ISSN=1664-0640

ABSTRACT=<p>There is a growing evidence for the rapid and robust antidepressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment preceded by 2-day period of manic symptoms.</p>