AUTHOR=Meier Sandra M. , Kähler Anna K. , Bergen Sarah E. , Sullivan Patrick F. , Hultman Christina M. , Mattheisen Manuel TITLE=Chronicity and Sex Affect Genetic Risk Prediction in Schizophrenia JOURNAL=Frontiers in Psychiatry VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2020.00313 DOI=10.3389/fpsyt.2020.00313 ISSN=1664-0640 ABSTRACT=

Schizophrenia (SCZ) is a severe mental disorder with immense personal and societal costs; identifying individuals at risk is therefore of utmost importance. Genomic risk profile scores (GRPS) have been shown to significantly predict cases-control status. Making use of a large-population based sample from Sweden, we replicate a previous finding demonstrating that the GRPS is strongly associated with admission frequency and chronicity of SCZ. Furthermore, we were able to show a substantial gap in prediction accuracy between males and females. In sum, our results indicate that prediction accuracy by GRPS depends on clinical and demographic characteristics.