AUTHOR=Kumar Ashutosh , Pareek Vikas , Singh Himanshu N. , Faiq Muneeb A. , Narayan Ravi K. , Raza Khursheed , Kumar Pavan 

TITLE=Altered Expression of a Unique Set of Genes Reveals Complex Etiology of Schizophrenia

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00906

DOI=10.3389/fpsyt.2019.00906

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> The etiology of schizophrenia is extensively debated, and multiple factors have been contended to be involved. A panoramic view of the contributing factors in a genome-wide study can be an effective strategy to provide a comprehensive understanding of its causality.</p><p><bold>Materials and Methods:</bold> GSE53987 dataset downloaded from GEO-database, which comprised mRNA expression data of post-mortem brain tissue across three regions from control (C) and age-matched subjects (T) of schizophrenia (N = Hippocampus [HIP]: C-15, T-18, Prefrontal cortex [PFC]: C-15, T-19, Associative striatum [STR]: C-18, T-18). Bio-conductor—affy—package used to compute mRNA expression, and further t-test applied to investigate differential gene expression. The analysis of the derived genes performed using the PANTHER Classification System and NCBI database. Further, a protein interactome analysis of the derived gene set was performed using STRING v10 database (<uri xlink:href="https://string-db.org/" xmlns:xlink="http://www.w3.org/1999/xlink">https://string-db.org/</uri>)</p><p><bold>Results:</bold> A set of 40 genes showed significantly altered (p &lt; 0.01) expression across all three brain regions. The analyses unraveled genes implicated in biological processes and events, and molecular pathways relating basic neuronal functions.</p><p><bold>Conclusions:</bold> The aberrant expression of genes maintaining basic cell machinery explains compromised neuronal processing in SCZ.</p>