AUTHOR=Vaeroy Henning , Schneider Frida , Fetissov Sergueï O. 

TITLE=Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00872

DOI=10.3389/fpsyt.2019.00872

ISSN=1664-0640

ABSTRACT=<p>Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and <italic>in vitro</italic> models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.</p>