AUTHOR=Bennabi Djamila , Haffen Emmanuel , Van Waes Vincent 

TITLE=Vortioxetine for Cognitive Enhancement in Major Depression: From Animal Models to Clinical Research

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00771

DOI=10.3389/fpsyt.2019.00771

ISSN=1664-0640

ABSTRACT=<p><bold>Objectives:</bold> Vortioxetine has already shown its efficacy in the acute and long-term treatment of major depressive disorder (MDD) and its potential interest in the prevention of relapse. The aim of this study was to review the current status of knowledge regarding its cognitive effects.</p><p><bold>Methods:</bold> We conducted a review of key data obtained from preclinical behavioral models and clinical trials in MDD focusing on vortioxetine-induced cognitive changes.</p><p><bold>Results:</bold> In animals, acute and chronic administration of vortioxetine improves performance on objective measures that cover a broad range of cognitive domains. In human, vortioxetine appears to be a useful treatment option in MDD patients with cognitive dysfunction.</p><p><bold>Conclusion:</bold> Vortioxetine constitutes a promising treatment for treatment of cognitive impairment in MDD, but its place in the therapeutic armamentarium still needs to be determined.</p>