AUTHOR=Son Sang Joon , Park Bumhee , Choi Jin Wook , Roh Hyun Woong , Kim Na-Rae , Sin Jae Eun , Kim Haena , Lim Hyun Kook , Hong Chang Hyung 

TITLE=Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00615

DOI=10.3389/fpsyt.2019.00615

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience-related FC in 112 older adults with mild cognitive impairment (MCI).</p><p><bold>Methods:</bold> Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/amygdala (AMG)/hippocampus (HP)/parahippocampal gyrus (PHG) FC according to the different levels of resilience scale.</p><p><bold>Results:</bold> Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (<italic>P</italic> &lt; 0.05, Bonferroni corrected), between the right inferior OFG and left PHG (<italic>P</italic> &lt; 0.05, Bonferroni corrected), and between the right middle OFG and left PHG (false discovery rate &lt; 0.05).</p><p><bold>Conclusion:</bold> Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.</p>