AUTHOR=Ruta Liliana , Chiarotti Flavia , Arduino Giuseppe Maurizio , Apicella Fabio , Leonardi Elisa , Maggio Roberta , Carrozza Cristina , Chericoni Natasha , Costanzo Valeria , Turco Nazarena , Tartarisco Gennaro , Gagliano Antonella , Allison Carrie , Baron Cohen Simon , Pioggia Giovanni , Muratori Filippo 

TITLE=Validation of the Quantitative Checklist for Autism in Toddlers in an Italian Clinical Sample of Young Children With Autism and Other Developmental Disorders

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00488

DOI=10.3389/fpsyt.2019.00488

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> The Quantitative Checklist for Autism in Toddlers (Q-CHAT) is parent-report screening questionnaire for detecting threshold and sub-threshold autistic features in toddlers. The Q-CHAT is a dimensional measure normally distributed in the general population sample and is able to differentiate between a group of children with a diagnosis of autism and unselected toddlers.</p><p><bold>Objectives:</bold> We aim to investigate the psychometric properties, score distribution, and external validity of the Q-CHAT in an Italian clinical sample of young children with autism versus children with developmental delay and typically developing children.</p><p><bold>Method:</bold> N = 126 typically developing children (TD), n = 139 children with autism, and n = 50 children presenting developmental delay (DD) were administered the Q-CHAT. Standardized measures of cognitive functions, language, and behaviors were also obtained.</p><p><bold>Results:</bold> The Q-CHAT scores were normally distributed and demonstrated adequate internal consistency and good item to total score correlations. The mean Q-CHAT score in the autism group was significantly higher than those found in the DD sample and TD children. No difference on the mean Q-CHAT score between DD and TD children was found. The accuracy of the Q-CHAT to discriminate between autism and TD was very good. Two different cut-points (27 and 31, respectively) maximized sensitivity and specificity for autism versus TD and DD, respectively. Finally, higher Q-CHAT scores were correlated with lower language and social communication skills.</p><p><bold>Conclusions:</bold> In clinical settings, the Q-CHAT demonstrated good psychometric properties and external validity to discriminate autism children not just from children with typical development but also from children with developmental delay.</p>