AUTHOR=Allen Paul , Moore Holly , Corcoran Cheryl M. , Gilleen James , Kozhuharova Petya , Reichenberg Avi , Malaspina Dolores 

TITLE=Emerging Temporal Lobe Dysfunction in People at Clinical High Risk for Psychosis

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00298

DOI=10.3389/fpsyt.2019.00298

ISSN=1664-0640

ABSTRACT=<p>Clinical high-risk (CHR) individuals have been increasingly utilized to investigate the prodromal phases of psychosis and progression to illness. Research has identified medial and lateral temporal lobe abnormalities in CHR individuals. Dysfunction in the medial temporal lobe, particularly the hippocampus, is linked to dysregulation of glutamate and dopamine <italic>via</italic> a hippocampal–striatal–midbrain network that may lead to aberrant signaling of salience underpinning the <italic>formation of delusions</italic>. Similarly, lateral temporal dysfunction may be linked to the <italic>disorganized speech and language impairments</italic> observed in the CHR stage. Here, we summarize the significance of these neurobiological findings in terms of emergent psychotic symptoms and conversion to psychosis in CHR populations. We propose key questions for future work with the aim to identify the neural mechanisms that underlie the development of psychosis.</p>