AUTHOR=Carrilho Carolina G. , Cougo Simone S. , Bombassaro Tatiane , Varella André Augusto B. , Alves Gilberto S. , Machado Sergio , Murillo-Rodriguez Eric , Malaspina Dolores , Nardi Antonio E. , Veras André B.
TITLE=Early Trauma and Cognitive Functions of Patients With Schizophrenia
JOURNAL=Frontiers in Psychiatry
VOLUME=10
YEAR=2019
URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00261
DOI=10.3389/fpsyt.2019.00261
ISSN=1664-0640
ABSTRACT=Aim: The following work aims to investigate the putative correlation between early trauma and cognitive functions, as well as psychotic symptoms and cognitive functions, in individuals diagnosed with schizophrenia.
Methods: A quantitative assessment was performed with 20 individuals diagnosed with schizophrenia according to the 5th edition of the Diagnostic and Statistical Manual (DSM-5) criteria and who were in ongoing outpatient treatment in Psychosocial Care Centres in Brazil. Clinical measurements comprised a semistructured clinical interview, a screening questionnaire for common mental disorders, the Positive and Negative Syndrome Scale (PANSS), and the Early Trauma Inventory Self-Report—Short Form (ETISR-SF). Cognitive assessment included Beta III test, Concentrated Attention (CA) test, Color Trails Test (CTT), and Visual Face Memory (VFM) test.
Results: Age-adjusted analysis showed a negative correlation between early trauma and visual memory performance (r = −0.585, p = 0.007) and negative symptoms and attention performance (r = −0.715, p = 0.000).
Conclusion: Although a cause–effect relationship cannot be firmly stated, an association between early trauma experience and cognitive impairment such as visual memory, as well as a relationship between negative symptoms and attention domains, is suggested by our preliminary findings. Future studies with larger sample sizes and prospective design will clarify the long-term effects of early exposure to trauma and its clinical meaning in terms of developing psychotic-related illness.