AUTHOR=Deng Shi-Ning , Yan Yu-Hua , Zhu Tai-Lin , Ma Bing-Ke , Fan Hui-Ran , Liu Yan-Mei , Li Wei-Guang , Li Fei 

TITLE=Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating

JOURNAL=Frontiers in Psychiatry

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00015

DOI=10.3389/fpsyt.2019.00015

ISSN=1664-0640

ABSTRACT=<p>Memantine hydrochloride is an uncompetitive N-methyl-D-aspartate (NMDA) antagonist for treatment of moderate-to-severe Alzheimer's disease. Several studies have shown that memantine can significantly correct the binge-like eating behavior in human and animal models. People with overeating behavior are more likely to be obese. Therefore, we suppose that memantine would be a good candidate for the treatment of obesity. In this study, memantine was shown to increase weight loss in obese mice induced by high fat diet. Memantine was shown to decrease food intake without inducing abdominal discomfort and anxiety, suggesting that this compound would be a good candidate drug for obesity control.</p>