AUTHOR=Borges Marcus Kiiti , Lopes Thais Nakayama , Biella Marina Maria , Siqueira Alaíse , Mauer Sivan , Aprahamian Ivan 

TITLE=Early-Onset Alzheimer Disease (EOAD) With Aphasia: A Case Report

JOURNAL=Frontiers in Psychiatry

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00469

DOI=10.3389/fpsyt.2018.00469

ISSN=1664-0640

ABSTRACT=<p><bold>Background:</bold> Alzheimer's disease (AD) is traditionally subdivided into early onset (EOAD) and late onset (LOAD). EOAD has an onset before age 65 years and accounts for 1–5% of all cases. Two main presentation types of AD are familial and sporadic.</p><p><bold>Case presentation:</bold> The authors present the case of a 68-year-old retired white man, with a college level educational background. At 55 years of age, the patient presented cognitive decline with short-term memory impairment and slowed, hesitant speech. At 57 years, he was unable to remember the way to work, exhibiting spatial disorientation. PET-CT: revealed hypometabolism and atrophy in the left temporal lobe and posterior region of the parietal lobes.</p><p><bold>Disease course:</bold> Evolving with difficulties in comprehension and sentence repetition over past 3 years and with global aphasia in past 6 months, beyond progressive memory impairment.</p><p><bold>Discussion:</bold> Possibly due to the young age and atypical presentation, and the diagnosis of EOAD is often delayed. To the best of our knowledge, this case can be classified as a sporadic EOAD with aphasia. Clinical variant and neuroimaging findings were crucial to the diagnosis and treatment of this atypical presentation of AD.</p>