AUTHOR=Ahmed Saeed , Virani Sanya , Kotapati Vijaya P. , Bachu Ramya , Adnan Mahwish , Khan Ali M. , Zubair Aarij , Begum Gulshan , Kumar Jeevan , Qureshi Mustafa , Ahmed Rizwan 

TITLE=Efficacy and Safety of Varenicline for Smoking Cessation in Schizophrenia: A Meta-Analysis

JOURNAL=Frontiers in Psychiatry

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00428

DOI=10.3389/fpsyt.2018.00428

ISSN=1664-0640

ABSTRACT=<p><bold>Objective:</bold> Smoking represents a major public health problem among patients with schizophrenia. To this end, some studies have investigated the efficacy of varenicline for facilitating smoking cessation in schizophrenia patients. The present review seeks to synthesize the results of these studies as well as document the reported side effects of using this medication.</p><p><bold>Methods:</bold> An electronic search was performed using five major databases: PubMed, Scopus, EMBASE, Web of Science, and Cochrane Library. Included in the current analysis were randomized clinical trials (RCTs) that have investigated the effect of varenicline in promoting smoking cessation in patients with schizophrenia. Risk of bias among included RCTs was assessed using the Cochrane Collaboration's quality assessment tool.</p><p><bold>Results:</bold> Among the 828 screened articles, only four RCTs, which involved 239 participants, were eligible for meta-analysis. In patients with schizophrenia, varenicline treatment when compared to placebo significantly reduced the number of cigarettes consumed per day [SMD (95% CI) = 0.89(0.57–1.22)] and expired carbon monoxide levels [SMD (95% CI) = 0.50 (0.06–0.94)] respectively.</p><p><bold>Conclusion:</bold> Despite a limited number of studies included in the meta-analysis, our results suggest that varenicline is an effective and safe drug to assist smoking cessation in patients with schizophrenia. Future large-scale well-designed RCTs are required to validate these findings.</p>