AUTHOR=Shin Jung-Won , Park Hyunwoo , Cho Yoonju , Lee Suck , Yoon Jiwon , Maeng Sungho TITLE=Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice JOURNAL=Frontiers in Psychiatry VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2017.00097 DOI=10.3389/fpsyt.2017.00097 ISSN=1664-0640 ABSTRACT=
The therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of fear memories, but not many reagents that block the relapse of extinguished fear are known. Radix Polygalae (RP) is an Asian herb used for sedation, and its ingredients have anxiolytic and antidepressant properties. As various neurological effects have been identified, we tested whether RP affects the relapse of fear. Freezing in response to a conditioned context and cues was used to measure the effects of RP in mice. In cohort 1 (