AUTHOR=Carle Guilhem , Touat Mehdi , Bruno Nicolas , Galanaud Damien , Peretti Charles-Siegfried , Valero-Cabré Antoni , Levy Richard , Azuar Carole 

TITLE=Acute Frontal Lobe Dysfunction Following Prefrontal Low-Frequency Repetitive Transcranial Magnetic Stimulation in a Patient with Treatment-Resistant Depression

JOURNAL=Frontiers in Psychiatry

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2017.00096

DOI=10.3389/fpsyt.2017.00096

ISSN=1664-0640

ABSTRACT=<p>The potential of repetitive transcranial magnetic stimulation (rTMS) to treat numerous neurological and psychiatric disorders has been thoroughly studied for the last two decades. Here, we report for the first time, the case of a 65-year-old woman suffering from treatment-resistant depression who developed an acute frontal lobe syndrome following eight sessions of low-frequency rTMS (LF-rTMS) to the right dorsolateral prefrontal cortex while also treated with sertraline and mianserin. The pathophysiological mechanisms underlying such an unexpected acute frontal lobe dysfunction are discussed in relation to the therapeutic use of LF-rTMS in combination with pharmacotherapy in depressed patients.</p>