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Ana Luiza Zaninotto1,2*
Jessica Elias Vicentini3
Felipe Fregni1
Priscila Aparecida Rodrigues2Cibele Botelho2Mara Cristina Souza de Lucia4
Wellingson Silva Paiva2
- 1Laboratory of Neuromodulation, Center for Clinical Research Learning, Harvard Medical School (HMS), Charlestown, MA, USA
- 2Department of Neurology, School of Medicine, University São Paulo (USP-SP), São Paulo, Brazil
- 3Department of Neurology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil
- 4Division of Psychology, School of Medicine, University São Paulo (USP-SP), São Paulo, Brazil
Neuropsychological and psychiatric disorders represent a major concern and cause of disabilities after the trauma, contributing to worse recovery after traumatic brain injury (TBI). However, the lack of well-defined parameters to evaluate patient’s psychiatric disorders leads to a wide range of diagnoses and symptoms. The aim of this study was to perform a review of literature in order to gather data of the most common scales and inventories used to assess and diagnose depression, anxiety, and posttraumatic stress disorder (PTSD) after TBI. We conducted a literature search via MEDLINE, PubMed, and Web of Science. We included reviews, systematic reviews, and meta-analysis studies, and we used the following keywords: “traumatic brain injury OR TBI,” “depression OR depressive disorder,” “anxiety,” and “posttraumatic stress disorder OR PTSD.” From 610 titles, a total of 68 systematic reviews or meta-analysis were included in the section “Results” of this review: depression (n = 32), anxiety (n = 9), and PTSD (n = 27). Depression after TBI is a more established condition, with more homogeneous studies. Anxiety and PTSD disorders have been studied in a heterogeneous way, usually as comorbidity with other psychiatric disorders. Some scales and inventories designed for the general community may not be appropriate for patients with TBI.
Introduction
Globally, traumatic injuries are responsible for more than five million deaths annually, and traumatic brain injury (TBI) is one of the leading causes of disabilities and death. It is estimated that 1.7 million cases of TBI occur each year in the United States (USA), resulting in 52,000 deaths (1). Therefore, TBI represents around one-third (30.5%) of all injury-related deaths in the USA (1).
Traumatic brain injury usually results in brain disorders, leading to a heterogeneous spectrum of morbidities, ranging from transitory disturbances to permanent symptoms (2–6). Cognitive and psychiatric disorders are the common causes of disabilities and may cause difficulties in recovery after TBI (7–10). In diffuse axonal injury, disruption of the neural circuitry between the prefrontal cortex and limbic system (11, 12) can result in mood disorders arising even weeks or months after the initial injury (13).
Gordon et al. (14) reviewed rehabilitation in TBI and highlighted the need for a better understanding of the dynamics of recovery. They argue that only a few studies used measures accepted as “gold standards” (14). In 2010, the National Institute of Neurological Disorders and Stroke (NINDS) Common Data Elements (CDE) was created to develop data standards for clinical research in patients with TBI (15). However, even with the proposal of some guidelines, psychiatric functions are still being assessed in a heterogeneous manner (16, 17). Therefore, the aim of this study is to summarize the literature, including reviews, systematic reviews, and meta-analyses, regarding the scales and inventories most commonly used to diagnose and evaluate depression, anxiety, and posttraumatic stress disorder (PTSD) in patients with TBI. To assess a large number of published articles, we used an original method in order to have a global view of the instruments used in diagnosis over the years.
Methods
We conducted a literature search via online databases including MEDLINE, PubMed, and Web of Science. We included reviews, systematic reviews, and meta-analysis studies. In our search, we used the following keywords: “traumatic brain injury OR TBI,” “depression OR depressive disorder,” “anxiety,” and “posttraumatic stress disorder OR PTSD.” Abstracts and full text were carefully read, and studies were included in our review if they fulfilled the following inclusion criteria: (a) description/citation of the scale, questionnaire, or inventory used, (b) published in a peer-reviewed journal, (c) description of quantitative assessment for diagnosis, (d) full text written in English, and (e) adult participants. We selected studies published up to February 2016.
Searching and data analysis were performed by Ana Luiza Zaninotto and Jessica Elias Vicentini, both of whom have experience with mental health intervention and clinical research in TBI. All reviews and full text were read by the two reviewers and were included if they met the above-mentioned inclusion criteria. This selection method follows previous literature (18).
Results
We reviewed 610 titles and abstracts and selected studies according to our inclusion and exclusion criteria. Of those, 362 studies were excluded, of which 248 were reviewed entirely (full text). Sixty-nine studies were included in the review focusing on one or more aspects of the following three topics of interest: (a) depression (n = 32), (b) anxiety (n = 9), and (c) PTSD (n = 27). Of the 68 studies, 11 studies had overlapping topics of interest, since they met criteria for more than one psychiatric disorder (17–27). The abstracts and full text that did not meet the inclusion criteria were excluded from the review (n = 541). The main reasons for exclusion were that the studies did not report the instruments used to assess the psychiatric disorders and/or the psychiatric assessment was not the center of the study (n = 447). The remaining excluded articles (n = 94) were either not related to TBI samples, focused on the neurological basis of the psychiatric disease, discussed pharmacological interventions, or did not focus on psychiatric disorders (depression, anxiety, or PTSD).
Each step of the search and review process is detailed in a flow diagram (Figure 1), based on the PRISMA work group (28).
FIGURE 1
Figure 1. Flow diagram.
In Table 1, we present studies (n = 31) that assessed depressive symptoms or diagnosed depression following TBI. Five of these were meta-analyses. Seven studies analyzed assessments of depression related to TBI in veterans, military personnel, or war-related injuries. We observed that the Beck Depression Inventory (BDI) was presented in all the studies, followed by Structured Clinical Interview for DSM (SCID) and Diagnostic and Statistical Manual (DSM) diagnosis criteria. For TBI populations, the BDI, Symptoms Checklist (SCL), and Center for Epidemiologic Studies-Depression Scale (CES-D) were the most cited self-reported scales. For diagnosis of depression, DSM criteria were the most commonly used, followed by International Classification of Diseases (ICD). The most commonly used instrument was the Hamilton Depression Rating Scale (HAM-D). Table 2 shows different instruments were cited to assess depression.
TABLE 1
Table 1. Characteristics of the studies and the scales and inventories used to assess depressive disorder after TBI.
TABLE 2
Table 2. Scales and inventories used to assess depressive disorder after TBI.
Table 3 shows the nine studies that assessed anxiety disorders after TBI. Eight of these studies overlapped with other psychiatric conditions. Just one review focused on the anxiety sequelae after TBI (99). The Hospital Anxiety and Depressive Symptoms Scale (HADS) was the most cited instrument to assess anxiety, followed by State-Trait Anxiety Inventory (STAI). The DSM criteria were most commonly used to diagnose anxiety. Table 4 shows the instruments cited in the anxiety reviews that were analyzed.
TABLE 3
Table 3. Characteristics of the studies and the scales and inventories used to assess anxiety disorder after TBI.
TABLE 4
Table 4. Scales and inventories used to assess anxiety disorder after TBI.
In our search, we found 26 reviews and meta-analyses related to PTSD and TBI. We identified two types of studies, one focusing on military veterans or war-related TBI (n = 13), and another focusing on a non-specific TBI population (n = 13) (Table 5). Table 6 shows a summary of the scales and inventories used to assess PTSD in TBI populations. The PTSD Checklist (PCL) is most commonly used to assess PTSD in veteran and military samples, followed by the Clinician-Administered PTSD Scale (CAPS). PTSD Checklist – Military version (PCL-M) and PTSD Checklist – Civilian version (PCL-C) were the most cited self-reported scales. DSM criteria were used to diagnose PTSD, while ICD was not cited in any of the studies we analyzed.
TABLE 5
Table 5. Characteristics of the studies and the scales and inventories used to assess PTSD after TBI.
TABLE 6
Table 6. Scales and inventories used to assess posttraumatic stress disorder (PTSD) after TBI.
Discussion
Depression
Major depression and dysthymia are frequently diagnosed using structured clinical interviews meeting DSM or ICD criteria. Depression often occurs in the first year after TBI (12). Estimates for posttraumatic depression range from 6 to 77% (151, 152), depending on diagnostic criteria, assessment methods, and timing post-trauma (22, 23, 152). Concomitant brain injury is a strong predictor of depression after TBI (13). In addition, poor mental health after TBI involves several factors, including young age at the time of injury, short duration between the injury and assessment, pain, lower levels of social support (153), and lack of hope (40). For those patients, consequences of depression include greater interpersonal difficulties, higher rates of unemployment (152), increased rates of distress, and problems with rehabilitation (154).
Some studies focus on specific TBI populations including the elderly, women, and veterans. Menzel (38) reviewed depression in the elderly after TBI, but the author found only one original study (104), leading to inconclusive findings. In their study, Levin et al. (104) assessed depressive symptoms by the Geriatric Depression Scale (GDS). Since this scale has been designed and standardized for geriatric populations with no history of TBI, there is a potential risk of overlapping the symptoms of TBI and depression. In addition, GDS cannot be used as a criterion for diagnostic assessment.
Seven studies addressed combat veterans with sustained TBI (18, 19, 22, 23, 31, 33, 36). They reported limited evidence that deficits and symptoms are distinct between veterans with or without a history of mild TBI (mTBI). O’Neil et al. (23) also highlighted a study (155) that showed an increased risk of suicide post-TBI compared to the non-TBI population. As we reported before, the BDI was the most cited inventory used in this sample. It contains 21 symptoms correlated with self-reported depression. The newer version of the BDI, the Beck Depression Inventory II (BDI-II), produced scores two points higher when compared to the oldest version for psychiatric outpatients (49). For this reason, comparisons between studies need to be carefully done.
One study addressed the literature focusing on women with TBI, comorbidity with depression, and hopelessness (40). The study analyzed symptoms both qualitatively and quantitatively. They concluded that mental health seems to deteriorate after TBI. Social isolation is of particular concern as a consequence of poor emotional functioning in these patients. In their study, the authors also reported on sex-based differences and limited data on the incidence of sex-specific depression.
Osborn et al. (17) showed the prevalence of major depression disorder (MDD) and dysthymia ranged from 14% using International Classification o Diseases (ICD-10) criteria to 43% using DSM-III criteria. For self-reported scales, the range of depression was between 16 and 33%. They found higher prevalence rates of depression using NFI than SCID-I, Schedules for Clinical Assessment in Neuropsychiatry (SCAN), or Mini-International Neuropsychiatric Interview (MINI). The occurrence of MDD and dysthymia appears to rise in the first 5 years after brain injury (from 21 to 43%). However, the majority of the studies used mixed TBI severity samples and did not report separate outcomes for these subgroups (17). Still, the HAM-D is wildly used to diagnose MDD in patients with TBI.
It is appropriate to use the standard diagnostic criteria for depression when evaluating persons with TBI. The CDE recommends scales and inventories to assess symptoms of depression in adults with TBI (15): the BDI-II, Brief Symptom Inventory-18 (BSI-18), CES-D, and Patient Health Questionnaire-9-Item (PHQ-9).
Anxiety
Anxiety disorders are frequently comorbid after TBI; there is a complex and multifaceted relationship, considering that premorbid anxiety is a predictor of the development of depression and anxiety disorders post-TBI (156).
Anxiety disorders post-TBI have multiple etiologies, from environmental to biological/genetic. Anxious reactions usually follow brain injury occurring in the setting of traumatic events, such as motor vehicle accidents, falls, and assaults (157). We observed in our results that just one study aimed to analyze the sequelae of anxiety disorders after TBI (99). The other studies focused on the overall mental condition, including assessment of anxiety. One study analyzed the overall mental condition in a heterogeneous sample of patients with acquired brain injury (20). Three studies selected homogeneous samples: patients with closed TBI (17) and veterans/military personnel with mTBI (22, 23).
Osborn et al. (17) did a meta-analysis focusing on the prevalence of post-TBI generalized anxiety disorder (GAD). The results showed that approximately 11% of the patients were diagnosed with GAD after TBI, ranging from 2 to 28%. Taking into consideration the type of instrument used, the diagnostic scale ICD-10 was related to a lower prevalence rate (2%) of GAD after TBI, whereas the DSM-III-R was related to a higher prevalence (19%) of GAD (17). For interview schedules, SCAN showed a lower prevalence of GAD (2%), while the Schedule for Affective Disorders and Schizophrenia (SADS) showed a higher prevalence (28%) (17). The authors report differences in anxiety rates depending on the stages of TBI recovery. Thus, the timing of assessment may impact the number and severity of the symptoms, leading to bias in the results (158). The meta-analysis also showed a non-significant increase in the number of anxiety cases in the first 5 years post-trauma (17).
Two anxiety scales are suggested by the CDE for TBI populations: the Kiddie-Schedule for Affective Disorders and Schizophrenia (K-SADS) and Neuropsychiatric Rating Schedule (NRS). Interestingly, these scales were not extensively reported in this review, and the NRS was not reported in any of them.
The authors also recommend assessing substance abuse as a comorbidity of psychiatric conditions, especially in anxiety disorders (22, 24). The CDE suggests some questionnaires for this purpose: the Substance Abuse Questions from the TBI Model Systems Database, Alcohol Use Disorders Identification Test: self-reported version (AUDIT), and Alcohol, Smoking, and Substance Use Involvement Screening Test (ASSIST).
Posttraumatic Stress Disorder
Posttraumatic stress disorder and GAD showed high prevalence after TBI and were both classified as anxiety disorders. In 2013, the DSM-5 classified PTSD as a trauma-stressor-related disorder, rather than an anxiety disorder. For this reason, we classified PTSD and anxiety disorders as separate psychiatric conditions.
In TBI patients, PTSD is usually related to a severe accident or injury, violent assault, domestic violence, war, or disaster (Criterion A – DSM-5). Prevalence rates of PTSD after TBI range from 3 to 59% (159, 160), while 43.9% of soldiers who reported loss of consciousness post-TBI met the criteria for PTSD (161). Our findings support previous results in which the heterogeneous range of diagnoses is due to the differences in assessment methods and methodologies of the original studies (111).
Depression, anxiety, and PTSD are usually comorbid conditions following TBI and may facilitate the persistence of its effects (162). Gill et al. (4) showed that psychological well-being is not predictive of the development of PTSD, but evidence suggests that individuals who have a history of psychological difficulties are at greater risk of developing PTSD after TBI.
Posttraumatic stress disorder is one of the most common mental health disorders affecting approximately 15% of veterans with no history of TBI. Nevertheless, the diagnosis rates of PTSD range from 33 to 65% in veterans with a history of TBI (163, 164). For this sample, the PCL is broadly used. The PCL-M and CAPS are the interview schedules most commonly used to assess PTSD in veterans and are recommended by the CDE (15). CAPS is considered the “gold standard” instrument for diagnosing and measuring the severity of PTSD, and it has been used with a variety of traumatized populations, including TBI (109, 165). There are different versions available, including CAPS to assess past-week, past-month, and lifetime symptoms. The PCL is a 17-item self-reported measure of PTSD symptoms and requires less time to complete than CAPS, which consists of a 30-item self-reported questionnaire. PCL is highly correlated with CAPS (r = 0.93), and it has favorable diagnostic efficiency (>0.70) and robust psychometric properties (165). For civilians with TBI, the PCL and CAPS are the most commonly used instruments to assess PTSD. However, the PCL-C and PTSD Checklist – Stressor specific (PCL-S) are preferable.
Overall, psychological variables, worsening general health, chronic pain, and somatic symptoms are associated with PTSD, especially in moderate to severe TBI. Comorbidities, such as PTSD and TBI, may unfavorably affect individuals more than suffering from any disorder alone (166). Some factors suggest how individuals with TBI might be more likely to develop PTSD. Somatic conditions and psychiatric disorders, such as PTSD, seem to perpetuate the illness condition in a loop (167). Those somatic conditions may present not only as risk factors but may also contribute to the persistence of other disorders, such as PTSD (4). This highlights the importance of therapy and rehabilitation for PTSD after TBI.
Brain Function and Mental Health Post-TBI
Symptoms of anxiety, depression, and irritability often occur after TBI and affect mood centers, including the hippocampus, amygdala, and prefrontal regions of the brain (168). Psychological factors are potential contributors to poor recovery after mTBI (8). Since TBI etiologies are diverse, understanding the role of the neurobiological basis for behavioral dysfunctions can be complex. The neuroanatomical location of the head injury can play a role in the development of depression (45, 169). However, only a small portion of patients may sustain damage to the particular location and with a severity level necessary to produce a psychiatric syndrome while preserving adequate cognitive function; thus, a biological gradient can be very difficult to detect (25). Premorbid factors associated with psychiatric disorders are inconclusive. Family history of psychiatric disorders seems to be a predictor of depression (169) or PTSD in individuals who have experienced TBI (45). In addition, females have a higher risk of developing acute PTSD after motor vehicle accidents (170). However, some authors did not find this association in premorbid psychiatric illness with the development of PTSD (171).
Acquired brain lesions, especially those involving the prefrontal cortex may have a prominent role in developing and maintaining executive functions. These functions encompass a set of skills that allow for people’s adjustment and adaptation in the face of new situations and daily operation. Therefore, changes in executive functions are among the most common consequences resulting from TBI (172, 173). Depressive symptoms can also affect cognitive processes, inhibiting a patient’s ability to return to daily activities over the short-term. Prefrontal cortex disruption may result in impulsive behaviors and a higher risk of substance use disorders (174). Thus, there is evidence that TBI may increase the risk of drug or alcohol abuse in persons without a history of substance abuse before the injury, especially if the damage involves the orbitofrontal cortex (175). In our review, only short reports attempted to find associations between mental health and substance abuse. Hesdorffer et al. (37) reported that changes in drug and alcohol use usually preceded the occurrence of TBI, increasing the risk of head injury. One important point is that many of the studies analyzed in the reviews used current alcohol or substance abuse as exclusion criteria, possibly camouflaging their frequency of occurrence.
Perspectives and Future Research
Considering the high incidence of TBI in the elderly (140–200 per 100,000 per year) and the relatively high prevalence of depression following TBI, it is reasonable to address the question of depression in the elderly following TBI (38). There is a gap in the literature addressing the evaluation and monitoring of elderly TBI patients.
One limitation related to veterans and military populations is that most of the analyzed data are from medical registries and clinical databases. It is necessary to have larger cohort studies, and it is also necessary to use standard methodology for the assessment of veterans and military populations.
Even in systematic reviews and meta-analyses, attrition bias may occur, as some studies showed that individuals who did not complete studies generally had more severe TBI (176–179) or, conversely, had less severe TBI (180). In addition, some studies did not control for confounding variables, such as the severity of trauma or the period post-TBI, reducing the generalizability of some results.
Many studies utilized self-report or semi-structured interviews for diagnosis. These results can lead to bias in the reported frequency of depressive disorder in this population. Self-report scales may not be reliable as patients with TBI may be unaware of their disabilities, and lack of awareness may lead to an underdiagnosis of psychiatric disorders (25). Another important variable relates to the recruitment of study participants. Outpatient and inpatient populations tend to vary in the intensity of their symptoms, particularly in the acute stage of trauma, when patients are often confused and disoriented. Many reviews analyzed mixed samples of trauma severity and different recruitment settings (17). Moreover, the majority of the instruments require that patients report their symptoms over the previous 2 weeks, and patients may have difficulty answering such questions or giving reliable responses, particularly in the acute stages of trauma.
Another important issue is the analysis of premorbid psychiatric conditions, a factor that may bias results. Finally, as we are reporting on specific information from selected reviews in the field, there is the risk of publication bias.
Conclusion
There is significant variability in the types of assessments used in the evaluation of psychiatric disorders after TBI, and consequently, there is also variability in the reported prevalence of such disorders. We analyzed meta-analyses and systematic reviews focusing on the most prevalent psychiatric conditions, and we observed a heterogeneous pattern related to their assessment and diagnosis in TBI populations. Depression after TBI is a well-established condition with homogeneous studies. Anxiety and PTSD disorders have been studied in a heterogeneous way, usually comorbid with other psychiatric disorders. The variability of clinical findings raises the importance of the instruments used to assess these patients. Finally, some scales and inventories designed for the general community may not be appropriate for patients with TBI (152).
Author Contributions
AZ – had the idea of the review, organized the search method, and wrote the manuscript. JV – helped to write the manuscript and did the tables. FF – reviewed the manuscript and helped the elaboration of the manuscript. PR – helped to write the manuscript. CB – helped on the tables review. ML – helped to review the manuscript. WP – reviewed the manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funding
We thank the National Counsel of Technological and Scientific Development, process number: 201809/2014-1 for the PhD scholarship.
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Keywords: traumatic brain injury, psychiatry, depression, anxiety, posttraumatic stress disorder, assessment, scales, inventory reporting, questionnaires
Citation: Zaninotto AL, Vicentini JE, Fregni F, Rodrigues PA, Botelho C, de Lucia MCS and Paiva WS (2016) Updates and Current Perspectives of Psychiatric Assessments after Traumatic Brain Injury: A Systematic Review. Front. Psychiatry 7:95. doi: 10.3389/fpsyt.2016.00095
Received: 03 February 2016; Accepted: 19 May 2016;
Published: 14 June 2016
Edited by:
Martin Heinze, Immanuel Klinik Rüdersdorf bei Berlin, GermanyReviewed by:
Taiwo Lateef Sheikh, Federal Neuropsychiatric Hospital, NigeriaAndres Ricardo Schneeberger, Psychiatrische Dienste Graubuenden, Switzerland
Copyright: © 2016 Zaninotto, Vicentini, Fregni, Rodrigues, Botelho, de Lucia and Paiva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ana Luiza Zaninotto, YXphbmlub3R0b0BuZXVyb21vZHVsYXRpb25sYWIub3Jn