AUTHOR=Liberg Benny , Rahm Christoffer 

TITLE=The Functional Anatomy of Psychomotor Disturbances in Major Depressive Disorder

JOURNAL=Frontiers in Psychiatry

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2015.00034

DOI=10.3389/fpsyt.2015.00034

ISSN=1664-0640

ABSTRACT=<p>Psychomotor disturbances (PMD) are a classic feature of depressive disorder that provides rich clinical information. The aim our narrative review was to characterize the functional anatomy of PMD by summarizing findings from neuroimaging studies. We found evidence across several neuroimaging modalities that suggest involvement of fronto-striatal neurocircuitry, and monoaminergic pathways and metabolism. We suggest that PMD in major depressive disorder emerge from an alteration of limbic signals, which influence emotion, volition, higher-order cognitive functions, and movement.</p>