AUTHOR=Smalheiser Neil R., Zhang Hui , Dwivedi Yogesh TITLE=Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness JOURNAL=Frontiers in Psychiatry VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2014.00006 DOI=10.3389/fpsyt.2014.00006 ISSN=1664-0640 ABSTRACT=
Major depressive disorder (MDD) is a major public health concern. Despite tremendous advancement, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small non-coding RNAs that control gene expression by modulating translation, mRNA degradation or stability of mRNA targets. The role of miRNAs in disease pathophysiology is emerging rapidly. Recently, we reported that miRNA expression is down-regulated in frontal cortex of depressed suicide subjects, and that rats exposed to repeated inescapable shock show differential miRNA changes depending on whether they exhibited normal adaptive responses or learned helpless (LH) behavior. Enoxacin, a fluoroquinolone used clinically as an anti-bacterial compound, enhances the production of miRNAs