AUTHOR=Kiss Tamás , Hoffmann William E., Scott Liam , Kawabe Thomas T., Milici Anthony J., Nilsen Erik A., Hajós Mihály TITLE=Role of Thalamic Projection in NMDA Receptor-Induced Disruption of Cortical Slow Oscillation and Short-Term Plasticity JOURNAL=Frontiers in Psychiatry VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2011.00014 DOI=10.3389/fpsyt.2011.00014 ISSN=1664-0640 ABSTRACT=
NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine, or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory. In spite of the widespread use of NMDAR antagonists in preclinical and clinical studies, our understanding of the mode of action of these drugs on brain circuits and neuronal networks is still limited. In the present study spontaneous local field potential (LFP), multi- (MUA) and single-unit activity, and evoked potential, including paired-pulse facilitation (PPF) in response to electrical stimulation of the ipsilateral subiculum were carried out in the medial prefrontal cortex (mPFC) in urethane anesthetized rats. Systemic administration of MK-801 (0.05 mg/kg, i.v.) decreased overall MUA, with a diverse effect on single-unit activity, including increased, decreased, or unchanged firing, and in line with our previous findings shifted delta-frequency power of the LFP and disrupted PPF (Kiss et al.,