AUTHOR=Höifödt Lidö Helga , Ericson Mia , Marston Hugh , Söderpalm Bo TITLE=A Role for Accumbal Glycine Receptors in Modulation of Dopamine Release by the Glycine Transporter-1 Inhibitor Org25935 JOURNAL=Frontiers in Psychiatry VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2011.00008 DOI=10.3389/fpsyt.2011.00008 ISSN=1664-0640 ABSTRACT=
Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc, prevents a further ethanol-induced dopamine elevation and robustly and dose-dependently decreases ethanol consumption in rats. Here we investigated whether Org25935 applied locally in nAc modulates dopamine release, and whether accumbal glycine receptors or NMDA receptors are involved in this tentative effect. We also addressed whether Org25935 and ethanol applied locally in nAc interact with dopamine levels, as seen after systemic administration. We used