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ORIGINAL RESEARCH article

Front. Plant Sci.
Sec. Plant Bioinformatics
Volume 15 - 2024 | doi: 10.3389/fpls.2024.1440589

Revealing the dynamic changes of metabolites and molecular mechanisms of chlorogenic acid accumulation during the leaf development of Vaccinium dunalianum based on multi-omic analyses

Provisionally accepted
Anmian Zhang Anmian Zhang 1Weicheng Li Weicheng Li 1Lihong Yang Lihong Yang 1Jiaxin Liu Jiaxin Liu 1Wenjin Duan Wenjin Duan 1Ping Zhao Ping Zhao 1Zhiyu Pu Zhiyu Pu 1,2Yong Ding Yong Ding 1*
  • 1 Southwest Forestry University, Kunming, Yunnan Province, China
  • 2 Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, Yunnan, China

The final, formatted version of the article will be published soon.

    Vaccinium dunalianum, a medicinal plant, is utilized for Quezui Tea production from its leaf buds and young leaves. Despite prior research on V. dunalianum revealing several medicinal compounds, the comprehensive variations in metabolites during its growth and development, along with the molecular mechanisms underlying high chlorogenic acid (CGA) yield, remain unclear. Through a joint analysis of transcriptomics and proteomics, our study first identified 15 key structural genes and 3 transcription factors influencing CGA biosynthesis in V. dunalianum, offering new evidence to understand its regulatory network. Furthermore, non-targeted metabolomics analysis provides the first extensive report on the metabolic profile of V. dunalianum, furnishing a valuable dataset for deeper exploration of its nutritional and medicinal value, and the development of a quality evaluation system for its product Quezui Tea. This study offers the most comprehensive molecular information on V. dunalianum, marking a significant step toward understanding and enhancing the plant's potential for medicinal and nutritional applications. Additionally, this study also reveals V. dunalianum holds promise as a natural antioxidant source for functional foods, providing data support for network pharmacology.

    Keywords: Vaccinium dunalianum, Quezui Tea, Chlorogenic acid (CGA), Transcriptomics, Proteomics, non-targeted metabolomics; network pharmacology

    Received: 29 May 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Zhang, Li, Yang, Liu, Duan, Zhao, Pu and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yong Ding, Southwest Forestry University, Kunming, 650224, Yunnan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.