ResultsIn the current study, 929 LRR-RLKs were identified in Triticum aestivum genome database using the BLAST and hidden Markov models (HMM) approach and divided into 14 clades. Chromosomal localization and synteny analysis revealed that TaLRR-RLKs were randomly distributed on all chromosomes with 921 collinear events. Through the cis-acting elements analysis, we observed that TaLRR-RLKs participated in hormone response, light response, development, metabolism, and response to environmental stress. The transcript level of 14 random selected TaLRR-RLKs from each subfamily was regulated by plant hormone treatment and Chinese wheat mosaic virus (CWMV) infection. The function of TaLRR-RLKs in wheat resistance to CWMV infection was further investigated by virus-induced gene silencing assay. Additionally, the accumulation of MeJA response genes, as well as CWMV RNA were not changed in the TaLRR-RLK silencing plants under MeJA treatment.