AUTHOR=Ai Likun , Fu Shiqi , Li Yong , Zuo Mei , Huang Wen , Huang Jian , Jin Zhichao , Chen Yang 

TITLE=Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues

JOURNAL=Frontiers in Plant Science

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1102411

DOI=10.3389/fpls.2022.1102411

ISSN=1664-462X

ABSTRACT=<p>Botanical pesticides are one of the sources of third-generation pesticides, which have received much attention at home and abroad in recent years due to their degradable and pollution-free advantages in nature. This article explored a concise approach toward synthesizing a series of novel L-pyroglutamic acid analogues from L-hydroxyproline. Furthermore, bioassay studies of these sulfonyl ester derivatives against <italic>Pyricularia oryzae</italic>, <italic>Fusarium graminearum</italic>, <italic>Alternaria brassicae</italic>, <italic>Valsa mali</italic>, and <italic>Alternaria alternariae</italic> showed moderate antifungal activity. For instance, <bold>C08a</bold> and <bold>C08l</bold> provide potential lead agents for controlling <italic>Fusarium graminearum</italic> because of their inhibitory activity.</p>