AUTHOR=Siriwattananon Konlavat , Manopwisedjaroen Suwimon , Shanmugaraj Balamurugan , Rattanapisit Kaewta , Phumiamorn Supaporn , Sapsutthipas Sompong , Trisiriwanich Sakalin , Prompetchara Eakachai , Ketloy Chutitorn , Buranapraditkun Supranee , Wijagkanalan Wassana , Tharakhet Kittipan , Kaewpang Papatsara , Leetanasaksakul Kantinan , Kemthong Taratorn , Suttisan Nutchanat , Malaivijitnond Suchinda , Ruxrungtham Kiat , Thitithanyanont Arunee , Phoolcharoen Waranyoo TITLE=Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates JOURNAL=Frontiers in Plant Science VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2021.682953 DOI=10.3389/fpls.2021.682953 ISSN=1664-462X ABSTRACT=
The emergence of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected global public health and economy. Despite the substantial efforts, only few vaccines are currently approved and some are in the different stages of clinical trials. As the disease rapidly spreads, an affordable and effective vaccine is urgently needed. In this study, we investigated the immunogenicity of plant-produced receptor-binding domain (RBD) of SARS-CoV-2 in order to use as a subunit vaccine. In this regard, RBD of SARS-CoV-2 was fused with Fc fragment of human IgG1 and transiently expressed in