AUTHOR=Alcântara André , Bosch Jason , Nazari Fahimeh , Hoffmann Gesa , Gallei Michelle , Uhse Simon , Darino Martin A. , Olukayode Toluwase , Reumann Daniel , Baggaley Laura , Djamei Armin TITLE=Systematic Y2H Screening Reveals Extensive Effector-Complex Formation JOURNAL=Frontiers in Plant Science VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2019.01437 DOI=10.3389/fpls.2019.01437 ISSN=1664-462X ABSTRACT=
During infection pathogens secrete small molecules, termed effectors, to manipulate and control the interaction with their specific hosts. Both the pathogen and the plant are under high selective pressure to rapidly adapt and co-evolve in what is usually referred to as molecular arms race. Components of the host’s immune system form a network that processes information about molecules with a foreign origin and damage-associated signals, integrating them with developmental and abiotic cues to adapt the plant’s responses. Both in the case of nucleotide-binding leucine-rich repeat receptors and leucine-rich repeat receptor kinases interaction networks have been extensively characterized. However, little is known on whether pathogenic effectors form complexes to overcome plant immunity and promote disease.