AUTHOR=Martignago Damiano , Bernardini Benedetta , Polticelli Fabio , Salvi Daniele , Cona Alessandra , Angelini Riccardo , Tavladoraki Paraskevi 

TITLE=The Four FAD-Dependent Histone Demethylases of Arabidopsis Are Differently Involved in the Control of Flowering Time

JOURNAL=Frontiers in Plant Science

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2019.00669

DOI=10.3389/fpls.2019.00669

ISSN=1664-462X

ABSTRACT=<p>In <italic>Arabidopsis thaliana</italic>, four FAD-dependent lysine-specific histone demethylases (LDL1, LDL2, LDL3, and FLD) are present, bearing both a SWIRM and an amine oxidase domain. In this study, a comparative analysis of gene structure, evolutionary relationships, tissue- and organ-specific expression patterns, physiological roles and target genes for the four Arabidopsis <italic>LDL/FLDs</italic> is reported. Phylogenetic analysis evidences a different evolutionary history for the four <italic>LDL/FLDs</italic>, while promoter activity data show that <italic>LDL/FLDs</italic> are strongly expressed during plant development and embryogenesis, with some gene-specific expression patterns. Furthermore, phenotypical analysis of loss-of-function mutants indicates a role of all four Arabidopsis <italic>LDL/FLD</italic> genes in the control of flowering time, though for some of them with opposing effects. This study contributes toward a better understanding of the <italic>LDL/FLD</italic> physiological roles and may provide biotechnological strategies for crop improvement.</p>