AUTHOR=Krieger Célia , Roselli Sandro , Kellner-Thielmann Sandra , Galati Gianni , Schneider Bernd , Grosjean Jérémy , Olry Alexandre , Ritchie David , Matern Ulrich , Bourgaud Frédéric , Hehn Alain TITLE=The CYP71AZ P450 Subfamily: A Driving Factor for the Diversification of Coumarin Biosynthesis in Apiaceous Plants JOURNAL=Frontiers in Plant Science VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2018.00820 DOI=10.3389/fpls.2018.00820 ISSN=1664-462X ABSTRACT=
The production of coumarins and furanocoumarins (FCs) in higher plants is widely considered a model illustration of the adaptation of plants to their environment. In this report, we show that the multiplication of cytochrome P450 variants within the CYP71AZ subfamily has contributed to the diversification of these molecules. Multiple copies of genes encoding this enzyme family are found in Apiaceae, and their phylogenetic analysis suggests that they have different functions within these plants. CYP71AZ1 from