AUTHOR=Pizzio Gaston A. , Hirschi Kendal D. , Gaxiola Roberto A. 

TITLE=Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)

JOURNAL=Frontiers in Plant Science

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2017.01572

DOI=10.3389/fpls.2017.01572

ISSN=1664-462X

ABSTRACT=<p>Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant <italic>Type I Proton-pumping Pyrophosphatase</italic> (H<sup>+</sup>-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate <italic>Arabidopsis</italic> H<sup>+</sup>-PPase (AVP1- <italic>Arabidopsis Vacuolar Proton-pump 1)</italic> subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H<sup>+</sup>-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity.</p>