AUTHOR=Clark Natalie M. , de Luis Balaguer Maria A. , Sozzani Rosangela 

TITLE=Experimental data and computational modeling link auxin gradient and development in the Arabidopsis root

JOURNAL=Frontiers in Plant Science

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2014.00328

DOI=10.3389/fpls.2014.00328

ISSN=1664-462X

ABSTRACT=<p>The presence of an auxin gradient in the <italic>Arabidopsis</italic> root is crucial for proper root development and importantly, for stem cell niche (SCN) maintenance. Subsequently, developmental pathways in the root SCN regulate the formation of the auxin gradient. Combinations of experimental data and computational modeling enable the identification of pathways involved in establishing and maintaining the auxin gradient. We describe how the predictive power of these computational models is used to find how genes and their interactions tightly control the formation of an auxin maximum in the SCN. In addition, we highlight known connections between signaling pathways involving auxin and controlling patterning and development in <italic>Arabidopsis</italic>.</p>