AUTHOR=Xia Ye , Yu Keshun , Gao Qing-ming , Wilson Ella , Navarre Duroy , Kachroo Pradeep , Kachroo Aardra 

TITLE=Acyl CoA Binding Proteins are Required for Cuticle Formation and Plant Responses to Microbes

JOURNAL=Frontiers in Plant Science

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2012.00224

DOI=10.3389/fpls.2012.00224

ISSN=1664-462X

ABSTRACT=<p>Fatty acids (FA) and lipids are well known regulators of plant defense. Our previous studies have shown that components of prokaryotic (plastidal) FA biosynthesis pathway regulate various aspects of plant defense. Here, we investigated the defense related roles of the soluble acyl CoA binding proteins (ACBPs), which are thought to facilitate the intracellular transport of FA/lipids. We show that <italic>ACBP3</italic> and <italic>4</italic> are required for maintaining normal lipid levels and that <italic>ACBP3</italic> contributes to the lipid flux between the prokaryotic and eukaryotic pathways. We also show that loss of <italic>ACBP3</italic>, <italic>4</italic>, or <italic>6</italic> impair normal development of the cuticle and affect both basal and resistance protein-mediated defense against bacterial and fungal pathogens. Loss of <italic>ACBP3</italic>, <italic>4</italic>, or <italic>6</italic> also inhibits the induction of systemic acquired resistance (SAR) due to the plants inability to generate SAR inducing signal(s). Together, these data show that ACBP3, ACBP4, and ACBP6 are required for cuticle development as well as defense against microbial pathogens.</p>