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PERSPECTIVE article
Front. Physiol.
Sec. Exercise Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1582777
This article is part of the Research TopicAdaptations and Responses to Respiratory InterventionsView all 3 articles
High-resistance Inspiratory Muscle Strength Training: A Promising Strategy for Improving Vascular Health in Chronic Kidney Disease
Provisionally accepted- University of Colorado Anschutz Medical Campus, Aurora, United States
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Patients with chronic kidney disease (CKD) demonstrate accelerated vascular aging which contributes to an increased risk of cardiovascular disease (CVD). Impaired vascular health in CKD is characterized by both functional and structural alterations to the vasculature including hypertension, arterial stiffness, vascular endothelial dysfunction, and autonomic dysfunction. These detriments persist despite pharmacological intervention. Habitual aerobic exercise can be protective of vascular health; however, the feasibility in patients with CKD is low due to numerous barriers to exercise. In this perspective we emphasize the need for novel and non-pharmacological strategies that can rescue vascular health and reduce the development of CVD in patients with CKD, explain the unique barriers to aerobic exercise in CKD, present a novel physical training intervention-high-resistance inspiratory muscle strength training (IMST) that addresses the barriers to exercise, and provide our opinion on why this lifestyle intervention may be particularly efficacious for patients with CKD.
Keywords: Chronic Kidney Disease, vascular health, lifestyle interventions, exercise training, inspiratory
Received: 24 Feb 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Lapierre-Nguyen, Buffington, Chonchol and Nowak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kristen L Nowak, University of Colorado Anschutz Medical Campus, Aurora, United States
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