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ORIGINAL RESEARCH article
Front. Physiol.
Sec. Computational Physiology and Medicine
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1575971
Characteristics and Hemolysis Analysis of Centrifugal Blood Pumps under Different Speed Modulations
Provisionally accepted- 1Beihang University, Beijing, China
- 2State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing Municipality, China
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Constant-speed methods are widely applied and studied in rotary blood pumps. However, various speed modulation which have been used in commercial blood pump lacks validation of the ventricular assist capability and hemolysis potential. This study investigates the hydrodynamic performance and hemolysis of a rotary ventricular assist device under sinusoidal speed modulation, focusing on the combined effects of phase, baseline speed, and speed fluctuation amplitude. Computational fluid dynamics (CFD) coupled with a dynamic cardiovascular model revealed that counter-phase modulation reduces hemolysis index (HI) fluctuations compared to in-phase conditions, while higher baseline speeds increase time-averaged HI due to prolonged exposure to non-physiological shear stress. Larger amplitudes expand the operational range but exacerbate HI variability. These findings demonstrate that phase synchronization critically balances pulsatility and hemocompatibility, providing actionable insights for adaptive speed control strategies in clinical practice.
Keywords: Centrifugal blood pump, Hemolysis, various speed modulation, computational fluid dynamics, flow field
Received: 13 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Su, Jin, Liu, Li and Gui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Donghai Jin, Beihang University, Beijing, China
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