Skip to main content

EDITORIAL article

Front. Physiol.
Sec. Respiratory Physiology and Pathophysiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1554396
This article is part of the Research Topic Respiratory Dysfunction in Neurological Disease and Injury: Novel Mechanisms and Potential Therapeutics View all 7 articles

Editorial: Respiratory Dysfunction in Neurological Disease and Injury: Novel Mechanisms and Potential Therapeutics

Provisionally accepted
Savannah Lusk Savannah Lusk 1*Robert Wadolowski Robert Wadolowski 2Mai K. ElMallah Mai K. ElMallah 3,4,5Carlos Mantilla Carlos Mantilla 6,7Teresa Pitts Teresa Pitts 8Irene C Solomon Irene C Solomon 2
  • 1 Baylor College of Medicine, Houston, United States
  • 2 Department of Physiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, United States
  • 3 Department of Pediatrics, School of Medicine, Duke University, Durham, North Carolina, United States
  • 4 Department of Cell Biology, School of Medicine, Duke University, Durham, North Carolina, United States
  • 5 Department of Neurobiology, School of Medicine, Duke University, Durham, North Carolina, United States
  • 6 Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Michigan, United States
  • 7 Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States
  • 8 Department of Speech, Language and Hearing Sciences, School of Health Professions, University of Missouri, Columbia, Missouri, United States

The final, formatted version of the article will be published soon.

    Understanding the intricate mechanisms governing respiration is pivotal for addressing the diverse and complex conditions that disrupt this essential function. Over the past two decades, significant advancements in our understanding of respiratory networks have opened new avenues for discovery, enabling a deeper exploration of diseases with overlapping etiologies and trajectories and promoting a deeper appreciation of relationships between neurological, developmental, and injury-induced respiratory dysfunction. With a focus on control of breathing, this Research Topic was developed and organized to highlight recent advances in various neurological-and injury-based models for respiratory dysfunction, emphasizing mechanisms of dysfunction and potential therapeutic approaches aimed at ameliorating dysfunction.Understanding basic neural circuit connectivity that regulates respiratory (dys)function is an essential first step. While brainstem nuclei have long been recognized as central components of respiratory maintenance, additional CNS sites have recently been implicated in higher-level modulation. In the review by Trevizan-Baú, et al., the authors explore the role of the amygdala, a key brain region in the temporal lobe, in regulating respiratory functions, including breathing, swallowing, coughing, airway smooth muscle contraction, and mucus secretion (Trevizan-Baú et al. 2024). The article also examines how amygdala dysfunction may contribute to respiratory and airway pathologies, such as those seen in anxiety disorders and airway diseases.Beyond the basic circuitry involved, mechanistic insights and therapeutic approaches necessitate discovery in the disease state. In the study by Barok et The authors declare that the research was conducted in the absence of any commercial or financial 115 relationships that could be construed as a potential conflict of interest. 116

    Keywords: breathing in disease, neurodegenerative respiratory pathology, developmental respiratory pathology, motoneuron and muscular respiratory pathology, Disordered breathing, respiratory therapeutics

    Received: 02 Jan 2025; Accepted: 09 Jan 2025.

    Copyright: © 2025 Lusk, Wadolowski, ElMallah, Mantilla, Pitts and Solomon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Savannah Lusk, Baylor College of Medicine, Houston, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.