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MINI REVIEW article

Front. Physiol.
Sec. Mitochondrial Research
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1550647
This article is part of the Research Topic Mechanisms and Novel Therapeutic Targets and Approaches for Mitochondrial Dysfunction in Neurological and Cardiovascular Diseases View all articles

Caveolin and Oxidative Stress in Cardiac Pathology

Provisionally accepted
Lauren Zadorozny Lauren Zadorozny Neil Supanekar Neil Supanekar Jiayue Du Jiayue Du Karthik Annamalai Karthik Annamalai Qing Yu Qing Yu Meijing Wang Meijing Wang *
  • Center for Surgical Sciences, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States

The final, formatted version of the article will be published soon.

    Caveolins interact with signaling molecules within caveolae and subcellular membranes. Dysregulation of caveolin function and protein abundance contributes to cardiac pathophysiological processes, driving the development and progression of heart disease. Reactive oxygen species (ROS) play a critical role in maintaining cellular homeostasis and are key contributors to the pathophysiological mechanisms of cardiovascular disorders. Caveolins have been shown to modulate oxidative stress and regulate redox homeostasis. However, the specific roles of caveolins, particularly caveolin-1 and caveolin-3, in regulating ROS production during cardiac pathology remain unclear. This mini-review article highlights the correlation between caveolins and oxidative stress in maintaining cardiovascular health and modulating cardiac diseases, specifically in myocardial ischemia, heart failure, diabetes-induced metabolic cardiomyopathy, and septic cardiomyopathy. A deeper understanding of caveolin-mediated mechanisms may pave the way for innovative therapeutic approaches to treat cardiovascular diseases.

    Keywords: Reactive Oxygen Species, Caveolae, Heart disease, Mitochondria, cardiomyopathy Moved (insertion) [5] Field Code Changed Tab stops: 0.5", Left Page 2: [1] Deleted Wang, Meijing 1/17/25 12:12:00 PM Page 2: [2] Formatted Wang, Meijing 1/17/25 12:23:00 PM Indent: Left: 0"

    Received: 23 Dec 2024; Accepted: 27 Jan 2025.

    Copyright: © 2025 Zadorozny, Supanekar, Du, Annamalai, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meijing Wang, Center for Surgical Sciences, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.