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ORIGINAL RESEARCH article

Front. Physiol.

Sec. Lipid and Fatty Acid Research

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1549392

This article is part of the Research Topic The Evolving Landscape of Lipid Mediators: Insights into Physiology and Cell Signaling View all 5 articles

Glucose-dependent insulinotropic polypeptide stimulates post-absorptive lipid secretion in the intestine

Provisionally accepted
Rong Wang Rong Wang Muhammad Saad Abdullah Khan Muhammad Saad Abdullah Khan Kundanika Mukherjee Kundanika Mukherjee Murooj Ghanem Murooj Ghanem Changting Xiao Changting Xiao *
  • University of Saskatchewan, Saskatoon, Saskatchewan, Canada

The final, formatted version of the article will be published soon.

    It is increasingly recognized that the intestine can retain a portion of dietary fats for secretion during the post-absorptive state, which has strong implications in metabolic diseases. The regulatory mechanisms of gut lipid storage and release are not well defined. Previous studies showed that the intestine releases locally stored fats in response to several stimulatory cues, such as glucose delivered into the intestinal lumen. It remains unknown how the intestine responds to nutrient signals in this phenomenon. Here we tested the effects of intravenous glucose delivery on intestinal lipid output during the post-absorptive state in mesenteric lymph duct cannulated rats. Compared with intraduodenal glucose delivery, intravenous glucose did not stimulate intestinal lipid output. Intraduodenal glucose was also associated with increases in blood levels of metabolic hormones, among which glucose-dependent insulinotropic peptide (GIP) levels were significantly higher at timepoints corresponding to increased lipid output than in intravenous glucose. Intraperitoneal GIP administration per se robustly stimulated intestinal lipid output. These results support a mechanism that involves glucose sensing at the apical side of the enterocytes and GIP as a potent stimulus for the release of lipid storage from the intestine.

    Keywords: intestine, Glucose, Glucose-dependent insulinotropic peptide, chylomicron, Triglycerides

    Received: 21 Dec 2024; Accepted: 21 Mar 2025.

    Copyright: © 2025 Wang, Khan, Mukherjee, Ghanem and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Changting Xiao, University of Saskatchewan, Saskatoon, S7N 5A2, Saskatchewan, Canada

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