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PERSPECTIVE article
Front. Physiol.
Sec. Vascular Physiology
Volume 16 - 2025 |
doi: 10.3389/fphys.2025.1548242
This article is part of the Research Topic Insights in Vascular Physiology: 2024 View all 6 articles
Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle
Provisionally accepted- 1 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
- 2 2. Department of Oncology and Metabolism, Healthy Lifespan Institute and MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing; 3. Bateson Centre, The University of Sheffield, Sheffield, England, United Kingdom
The mean life expectancy continues to increase world-wide. However, this extended lifespan trend is not accompanied by health span, or years of healthy life. Understanding the fundamental mechanisms responsible for the switch from health to morbidity with ageing are key to identifying potential therapeutic targets to decrease age-associated morbidity and increase years spent in good health. The leading cause of morbidity in Europe are diseases of the circulatory system and diseases of the nervous system and cognitive disorders are among the top-ten.Cerebrovascular ageing is therefore of particular importance as it links circulatory disease to brain functions, cognition, and behavior. Despite major progress in brain research and related technologies, little is known on how the cerebrovascular network changes its properties as ageing proceeds. Importantly, we do not understand why this is different in different individuals in what concerns rate of dysfunction and its downstream impact on brain function. Here we explore how the zebrafish has evolved as an attractive complementary ageing model and how it could provide key insights to understanding the mechanisms underlying cerebrovascular ageing and downstream consequences.
Keywords: Zebrafish, Brain, Telomere, Telomerase, cerebrovascular
Received: 19 Dec 2024; Accepted: 21 Jan 2025.
Copyright: © 2025 Malkinson and Henriques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guy Malkinson, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
Catarina M Henriques, 2. Department of Oncology and Metabolism, Healthy Lifespan Institute and MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing; 3. Bateson Centre, The University of Sheffield, Sheffield, S10 2TN, England, United Kingdom
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