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REVIEW article
Front. Physiol.
Sec. Mitochondrial Research
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1548194
This article is part of the Research Topic Mitochondrial Pathophysiology in Cardiomyopathy and Cardiac Senescence View all articles
Mechanisms Underlying Targeted Mitochondrial Therapy for Programmed Cardiac Cell Death
Provisionally accepted- 1 Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
- 2 Southwest Medical University, Luzhou, Sichuan, China
- 3 Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China
Heart diseases are common clinical diseases, such as cardiac fibrosis, heart failure, hypertension and arrhythmia. Globally, the incidence rate and mortality of heart diseases are increasing by years. The main mechanism of heart disease is related to the cellular state. Mitochondrion is the organ of cellular energy supply, participating in various signal transduction pathways and playing a vital role in the occurrence and development of heart disease. This review summarizes the cell death patterns and molecular mechanisms associated with heart disease and mitochondrial dysfunction.The heart is an organ that has an essential role in human body, with its primary functions to pump blood, provide pressure for blood flow, and supply oxygen and nutrients to cells throughout the body to maintain life activities. Mitochondria are
Keywords: Mitochondria, cardiomyocyte, PCD, ferroptosis, Autophagy, Apoptosis, pyroptosis, cuproptosis
Received: 19 Dec 2024; Accepted: 27 Mar 2025.
Copyright: © 2025 Li, Jing, Zhao, Xiong, Zeng and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tao Li, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China
Jun Jiang, Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China
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