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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Biophysics
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1537537
This article is part of the Research Topic Multidimensional Physiology: Novel Techniques and Discoveries with Bioimpedance Measurements, Volume II View all 5 articles

Optimized Measurement Methods and Systems for the Dielectric Properties of Active Biological Tissues in the 10Hz-100MHz Frequency Range

Provisionally accepted
Lei Wang Lei Wang 1*Yueying Shi Yueying Shi 2Xiaoxiao Bai Xiaoxiao Bai 1Jingrong Yang Jingrong Yang 1Xinyu Wu Xinyu Wu 1
  • 1 Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China
  • 2 School of Stomatology, Xi'an Medical University, Xi'an, China

The final, formatted version of the article will be published soon.

    The dielectric properties of active biological tissues within the 10Hz-100MHz frequency range contain rich information about tissue morphology and function. Accurately understanding the dielectric properties of active human tissues holds significant value for disease diagnosis and electromagnetic protection. However, accurately measuring these properties has been challenging due to factors such as electrode polarization and distribution parameters. This study has developed a dual-purpose measuring cell that supports both four-electrode and two-electrode impedance measurements. Leveraging this development, we have established a system and methodology that is well-suited for the dielectric property measurement of active biological tissues within the frequency range of 10Hz to 100MHz. Our measurements of dielectric properties in NaCl solutions of varying concentrations and pig liver tissues demonstrate the system's high accuracy and repeatability. For NaCl solutions, the maximum relative deviation is only 6.34%, with an average deviation of less than 1.5%. For pig liver tissues, the overall relative deviation is below 6%. Through the integration of the four-electrode and two-electrode measurement systems, we have successfully addressed the challenges of electrode polarization at low frequencies and the influence of distribution parameters at high frequencies, achieving a significant improvement in measurement accuracy across the spectrum.

    Keywords: dielectric properties, active biological tissue, 10Hz-100MHz frequency range, dualpurpose measuring cell, Electrode polarization, Distributed parameters, Measurement correction

    Received: 01 Dec 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Wang, Shi, Bai, Yang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lei Wang, Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.