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REVIEW article
Front. Physiol.
Sec. Metabolic Physiology
Volume 16 - 2025 |
doi: 10.3389/fphys.2025.1537231
Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment
Provisionally accepted- Renmin Hospital of Wuhan University, Wuhan, China
The circadian clock, an innate timing mechanism, governs a variety of physiological activities by producing near-24-hour cycles in gene expression. These cycles are reflected in patterns of metabolism and behavior. This system consists of two parts: one is the central clock located in the suprachiasmatic nucleus of the hypothalamus, and the other is the peripheral clock located in tissues throughout the body. Glucokinase, also termed hexokinase 4, is a member of the hexokinase family. It acts as a glucose sensor, plays a pivotal role in glucose homeostasis. Here, we review the role of circadian rhythm in glucose metabolism across various tissues, look into the molecular mechanism of circadian disruption involvement in glucose metabolism and diabetic complications, with a particular focus on the role of glucokinase. Finally, we propose potential strategies for effectively treating metabolic disorders and diabetic complications by modulating circadian rhythm glucokinase.
Keywords: Circadian Rhythm, Disruption, glucose metabolism, diabetes, diabetic complications, Glucokinase;
Received: 30 Nov 2024; Accepted: 04 Feb 2025.
Copyright: © 2025 Zhang, Wang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ling Gao, Renmin Hospital of Wuhan University, Wuhan, China
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