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REVIEW article
Front. Physiol.
Sec. Skeletal Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1527814
TNF receptor-associated factors (TRAFs): Promising Targets of Natural Products for the Treatment of Osteoporosis
Provisionally accepted- 1 Hebei Medical University, Shijiazhuang, Hebei Province, China
- 2 Xingtai City People's Hospital, Xingtai, China
- 3 Graduate School, Chengde Medical University, Chengde, Shanghai Municipality, China
Tumor necrosis factor receptor-associated factors (TRAFs) are crucial intracellular signaling proteins in bone homeostasis. TRAFs mediate pathways associated with bone remodeling, particularly in response to inflammatory stimuli, influencing osteoclast differentiation and function. Dysregulation of TRAF-mediated signaling contributes significantly to osteoporosis, a condition marked by increased bone resorption and fragility. Natural products, with their anti-inflammatory and antioxidant properties, offer promising therapeutic potential by targeting TRAF-associated pathways to inhibit excessive osteoclast activity and promote bone formation. This review explores the mechanisms by which natural compounds modulate TRAF signaling in osteoclastogenesis and osteoblastogenesis, providing insights into their potential for osteoporosis treatment.
Keywords: common genes, such as SNAP25, AQP4, SV2B, KCND3, ABCA2, CD163, CD14
Received: 15 Nov 2024; Accepted: 07 Mar 2025.
Copyright: © 2025 Yang, Zhao and Pang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lili Zhao, Xingtai City People's Hospital, Xingtai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.