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REVIEW article
Front. Physiol.
Sec. Skeletal Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1524100
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders
Provisionally accepted- Affiliated Hospital of Guizhou Medical University, Guiyang, China
With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well as a substantial economic burden on society. The advancements in conservative and surgical interventions for MSDs have been remarkable in recent years; however, the current treatment modalities still fall short of meeting the optimal requirements of patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its remarkable antioxidative, anti-inflammatory, and anti-apoptotic properties. It has been found that Prdx6 is involved in multiple system diseases, including MSDs; however, the exact role of Prdx6 in MSDs is still lacking. This study aimed to summarize the structure, regulatory mechanism, and potential function of Prdx6. These findings may demonstrate Prdx6 as a novel target for inhibiting the advancement of MSDs.
Keywords: Peroxiredoxin 6, Prdx6, musculoskeletal disorders, MSDs, Cell Death, Oxidative Stress, Inflammation
Received: 14 Nov 2024; Accepted: 27 Mar 2025.
Copyright: © 2025 Sun, Xu, Xiong, Liu, Ning and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xu Ning, Affiliated Hospital of Guizhou Medical University, Guiyang, China
Yong Zhuang, Affiliated Hospital of Guizhou Medical University, Guiyang, China
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