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REVIEW article
Front. Physiol.
Sec. Red Blood Cell Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1523448
This article is part of the Research Topic Heme Physiology and Pathology View all 5 articles
Role of Gut Microbiota in Thalassemia: A Review of Therapeutic Prospects
Provisionally accepted
Guanjun Chen 1
Yulan Li 1 Wei Shirui 2 Zheshu Kuang 3
Guo Weiming 1 Jianbin Qin 1 Xinyu Wang 1 Tianjun Huang 1 Youlin Li 1 Chunjiang Zhu 1*- 1 Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Region, China
- 2 Shandong Second Medical University, Weifang, Shandong Province, China
- 3 Chenzhou Third People's Hospital, Chenzhou, Hunan Province, China
In recent years, the study of gut microbiota has gradually become a research hotspot in the field of medicine, as gut microbiota dysbiosis is closely related to various diseases. Thalassemia, as a hereditary hemoglobinopathy, has a complex pathophysiological mechanism, and traditional treatment methods show limited efficacy. With a deeper understanding of the gut microbiome, researchers have begun to focus on its role in the pathogenesis of thalassemia and its therapeutic effects. This article aims to review the role of gut microbiota in thalassemia and its potential therapeutic prospects, analyze the latest research findings, and explore the impact and mechanisms of gut microbiota on patients with thalassemia, with the goal of providing new ideas and directions for future research and clinical treatment of thalassemia.
Keywords: Thalassemia, Gut Microbiota, Therapeutic prospects, Research progress, Probiotics
Received: 06 Nov 2024; Accepted: 05 Mar 2025.
Copyright: © 2025 Chen, Li, Shirui, Kuang, Weiming, Qin, Wang, Huang, Li and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chunjiang Zhu, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Region, China
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