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REVIEW article
Front. Physiol.
Sec. Invertebrate Physiology
Volume 16 - 2025 |
doi: 10.3389/fphys.2025.1507059
Alteration Of Mitochondrial Function in Arthropods During arboviruses Infection: A review of the literature
Provisionally accepted- 1 Centro de Investigación Sobre Enfermedades Infecciosas. Instituto Nacional de Salud Pública., Cuernavaca, Morelos, Mexico
- 2 Centro de Investigación Biomédica Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS)., Puebla, Mexico
Arthropods serve as vectors for numerous arboviruses responsible for diseases worldwide. Despite their medical, veterinary, and economic significance, the interaction between arboviruses and arthropods remains poorly understood. Mitochondria in arthropods play a crucial role by supplying energy for cell survival and viral replication. Some arboviruses can replicate within arthropod vectors without harming the host. Successful transmission depends on efficient viral replication in the vector's tissues, ultimately reaching the salivary glands for transmission to a vertebrate host, including humans, via blood-feeding. This review summarizes current knowledge of mitochondrial function in arthropods during arbovirus infection, highlighting gaps compared to studies in mammals and other pathogens relevant to arthropods. It emphasizes mitochondrial processes in insects that require further investigation to uncover the mechanisms underlying arthropod-borne transmission.
Keywords: Mitochondria, Arthropods, Infection, Arbovirus, metabolite
Received: 07 Oct 2024; Accepted: 20 Jan 2025.
Copyright: © 2025 Santana-Román, Ramírez-carreto, Maycotte and Pando-Robles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Victoria Pando-Robles, Centro de Investigación Sobre Enfermedades Infecciosas. Instituto Nacional de Salud Pública., Cuernavaca, Morelos, Mexico
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