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REVIEW article
Front. Physiol.
Sec. Redox Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1485367
Oxidative Stress in Periodontitis and the Application of Antioxidants in Treatment: A Narrative Review
Provisionally accepted
WEI LIU 1,2*
Daoyu Guo 2*- 1 School of Business, Huzhou University, Huzhou, China
- 2 Qilu Medical University, Zibo City, Shandong, China
Periodontitis has turned into a general oral disease defined by chronic inflammation of the gums and helping tissues of the teeth. It dramatically influences both oral and systemic health and is a main trigger of tooth loss. Periodontitis is tightly linked to oxidative stress, and evidence reveals the utilization of certain antioxidants in related treatments. Our review delves into literature in periodontitis, centering on the latest therapeutic strategies and mechanistic evidences. This review starts by depicting the epidemiological features and pathogenic mechanisms of periodontitis, highlighting the vital mechanism of microbial community modefications, host immune responses, and genetic factors in disease development. Existing treatment approaches for periodontitis involve mechanical cleaning, antibiotic therapy, surgical interventions, and pharmacological treatments, with a comprehensive exploration on the strengths and limitations of each strategy and their related clinical utilizations. Besides, this review investigates emerging therapies, like anti-inflammatory treatments, immune modulation therapies, and biotechnological utilization in the control of periodontitis. It particularly stresses the protective effects of antioxidants and their mechanistic researches in periodontitis, highlighting their potential in slowing inflammatory responses and boosting tissue repair. Ultimately, our review intends to the concept of individual therapy and investigates future directions, comprising the utilization of precision medicine in periodontitis control and the individual design of treatment utilization.
Keywords: Oxidative Stress, Periodontitis, Antioxidants, Inflammation, tissue repair
Received: 06 Sep 2024; Accepted: 18 Mar 2025.
Copyright: © 2025 LIU and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
WEI LIU, School of Business, Huzhou University, Huzhou, China
Daoyu Guo, Qilu Medical University, Zibo City, 255213, Shandong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.