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ORIGINAL RESEARCH article
Front. Physiol.
Sec. Metabolic Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1463597
Identification of potential miRNA biomarkers for neurobrucellosis diagnosis
Provisionally accepted
Meiling Liu 1
Liping Feng 2 Shujun Shi 1 Yuzhou Guo 1 Menghan Lv 1 Zhengyu Li 1 Xintian Wang 1
Hao Yang 1
Zhelin Zhang 1*- 1 Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China
- 2 Xing'an League Disease Prevention and Control Center, Ulanhot,, China
In this research, we identified four potential biomarkers (miR-342-3p, miR-576-5p, miR-15b-5p, and miR-499a-5p) for diagnosing NB. Furthermore, we developed a new diagnostic signature for NB using two miRNAs (miR-576-5p and miR-499a-5p). This signature demonstrated promising diagnostic capabilities in both in-house and validation cohorts. The discovery of reliable biomarkers is crucial for the early and precise detection of neurological disorders. We believe that our findings may provide valuable contributions to the field of NB research.
Keywords: Neurobrucellosis, miRNAs, Cerebrospinal fluids, miR-499a-5p, miR-576-5p
Received: 12 Jul 2024; Accepted: 18 Feb 2025.
Copyright: © 2025 Liu, Feng, Shi, Guo, Lv, Li, Wang, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhelin Zhang, Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China
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