Skip to main content

ORIGINAL RESEARCH article

Front. Physiol.
Sec. Cardiac Electrophysiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1529426

Atrioventricular nodal reentrant tachycardia onset, sustainability, and spontaneous termination in rabbit atrioventricular node model with autonomic nervous system control

Provisionally accepted
Maxim Ryzhii Maxim Ryzhii 1*Elena Ryzhii Elena Ryzhii 2
  • 1 University of Aizu, Aizuwakamatsu, Japan
  • 2 Fukushima Medical University, Fukushima, Fukushima, Japan

The final, formatted version of the article will be published soon.

    Atrioventricular nodal reentrant tachycardia (AVNRT) is one of the most common types of paroxysmal supraventricular tachycardia. The activity of the autonomic nervous system (ANS) is known to influence episodes of AVNRT, yet the precise mechanisms underlying this effect remain incompletely understood. In this study, we update our compact multifunctional model of the rabbit atrioventricular (AV) node with ANS control to simulate AVNRT. The refractoriness of the model cells is adjusted by a specific ANS coefficient, which impacts the effective refractory periods, conduction delays, and intrinsic frequency of pacemaker cells. Using this model, we investigate the onset, sustainability, and spontaneous termination of typical slow-fast and atypical fast-slow forms of AVNRT under ANS modulation. The conditions for the onset and sustainability of AVNRT can exist independently in various combinations. Differences in the effective refractory periods of the slow and fast pathways of the AV node during anterograde and retrograde conduction determine the specific form of AVNRT. For the first time, a computer model reveals the potential to identify hidden processes within the AV node, thereby bringing us closer to understanding the role of ANS control in AVNRT. The results obtained are consistent with clinical and experimental data and represent a novel tool for studying the electrophysiological mechanisms behind this type of arrhythmia.

    Keywords: Atrioventricular Node, rabbit heart model, Aliev-Panfilov model, Dual pathway, Autonomic Nervous System, AVNRT, Effective Refractory Period, Computer Simulation

    Received: 16 Nov 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Ryzhii and Ryzhii. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maxim Ryzhii, University of Aizu, Aizuwakamatsu, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.