This article is a correction to:
Between-Subject and Within-Subject Variation of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest
Jonas Böcker
Marie-Therese Schmitz1,2
Uwe Mittag
Jens Jordan
Jörn Rittweger- 1Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany
- 2Institute of Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany
- 3Chair of Aerospace Medicine, University of Cologne, Cologne, Germany
- 4German Aerospace Center, Head of Institute of Aerospace Medicine, Cologne, Germany
- 5Department of Pediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany
A Corrigendum on
Between-subject and within-subject variation of muscle atrophy and bone loss in response to experimental bed rest
by Böcker J, Schmitz M-T, Mittag U, Jordan J and Rittweger J (2022). Front. Physiol. 12:743876. doi: 10.3389/fphys.2021.743876
In the published article, there were some errors.
A correction has been made to the Abstract. The sentences previously stated:
The vast majority (82.6%) of the individual responses pci exceeded the 95% confidence interval defined by UMeas, indicating significant and substantial BSV, which was greater for bones than for muscles, especially at the epiphyseal measurement sites … These results demonstrate the existence of substantial BSV bone, and that it is partly driven by WSV, and likely also by physical activity and dietary habits prior to bed rest. In addition, genetic and epigenetic variation could potentially explain BSV, but not WSV.
The corrected sentences appear below:
The majority (59.1%) of the individual responses pci exceeded the 95% confidence interval defined by UMeas, indicating significant and substantial BSV, which was greater for bones than for muscles, especially at the diaphyseal measurement sites…. These results demonstrate the existence of substantial bone BSV and that it is partly driven by WSV and likely also by physical activity and dietary habits prior to bed rest.
A correction has been made to Results, paragraph 2. The sentences previously stated:
As can be seen from Figure 3, the vast majority (82.6%) of the observed individual percent change pci exceeds the confidence intervals, indicating significant and substantial BSV. By subtracting the calculated UMeas from UObs, UIR was calculated (Table 4).
Figure 3
Figure 3. Chart of the individual percent change (pci) by measurement sites with (A) CSA at MUSCLE_38, (B) CSA at MUSCLE_66, (C) BMC at TIBIA_04, (D) BMC at TIBIA_38, (E) BMC at TIBIA_66, and (F) BMC at TIBIA_98, where the numbers indicate the relative measurement position regarding the entire tibia length from distal to proximal. The color indicates the bed rest duration and the shape represents the study. Each chart is separated by the studies that performed measurements at the measurement site. Mean of the pc as dashed line, upper and lower limit of the 95%-confidence interval based on measurement uncertainty UMeas as solid lines. Most pci exceed the confidence interval, indicating significant between-subject variation.
The corrected sentences appear below:
As can be seen from Figure 3, the majority (59.1%) of the observed individual percent change pci exceeds the confidence intervals, indicating significant and substantial BSV. However, the BSV was greater for bone (65.9%) than for muscle (34.8%), and the BSV was greater for the diaphysis (71.0%) than for the epiphyseal measurement sites (60.2%).
A correction has been made to Discussion, subsection Between-Subject Variation. The sentences previously stated:
Turning to between-subject variation, Figure 3 and Table 4 clearly demonstrate that it exists, both for bone loss as well as for muscle wasting, and that between-subject variation was greater for muscle than for bone measures. In Figure 3, measurement uncertainty values were remarkably small for TIBIA_04, TIBIA_38 and TIBIA_66, and substantially larger for TIBIA_98 and the muscle sites. Regardless of the confidence interval width, the vast majority (82.6%) of the individual changes exceeded the interval.
The corrected sentences appear below:
Turning to between-subject variation, Figure 3 and Table 4 clearly demonstrate that it exists, both for bone loss as well as for muscle wasting, and that between-subject variation was greater for bone than for muscle measures. In Figure 3, measurement uncertainty values were remarkably small for TIBIA_04, TIBIA_38 and TIBIA_66, and substantially larger for TIBIA_98 and the muscle sites. Regardless of the confidence interval width, the majority (59.1%) of the individual changes exceeded the interval.
A correction has been made to Figure 3 caption.
FIGURE 3 Chart of the individual percent change (pci) by measurement sites with (A) CSA at MUSCLE_38, (B) CSA at MUSCLE_66, (C) BMC at TIBIA_04, (D) BMC at TIBIA_38, (E) BMC at TIBIA_66, and (F) BMC at TIBIA_98, where the numbers indicate the relative measurement position regarding the entire tibia length from distal to proximal. The color indicates the bed rest duration and the shape represents the study. Each chart is separated by the studies, who performed measurements at the measurement site. Mean of the pc as dashed line, upper and lower limit of the 95%-confidence interval based on measurement uncertainty UMeas as solid lines. The vast majority of pci exceeds the confidence interval indicating significant and substantial between-subject variation.
The corrected caption appears below.
FIGURE 3 Chart of the individual percent change (pci) by measurement sites with (A) CSA at MUSCLE_38, (B) CSA at MUSCLE_66, (C) BMC at TIBIA_04, (D) BMC at TIBIA_38, (E) BMC at TIBIA_66, and (F) BMC at TIBIA_98, where the numbers indicate the relative measurement position regarding the entire tibia length from distal to proximal. The color indicates the bed rest duration and the shape represents the study. Each chart is separated by the studies, who performed measurements at the measurement site. Mean of the pc as dashed line, upper and lower limit of the 95%-confidence interval based on measurement uncertainty UMeas as solid lines. The vast majority of pci exceeds the confidence interval indicating significant and substantial between-subject variation.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
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Keywords: between-subject variation, within-subject variation, measurement uncertainty, bed rest, muscle atrophy, bone loss
Citation: Böcker J, Schmitz M-T, Mittag U, Jordan J and Rittweger J (2025) Corrigendum: Between-subject and within-subject variation of muscle atrophy and bone loss in response to experimental bed rest. Front. Physiol. 15:1528096. doi: 10.3389/fphys.2024.1528096
Received: 14 November 2024; Accepted: 02 December 2024;
Published: 03 January 2025.
Edited and reviewed by:
Richard D. Boyle, National Aeronautics and Space Administration (NASA), United StatesCopyright © 2025 Böcker, Schmitz, Mittag, Jordan and Rittweger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jonas Böcker, am9uYXMuYm9lY2tlckBkbHIuZGU=