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MINI REVIEW article

Front. Physiol.
Sec. Vascular Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1522471
This article is part of the Research Topic Unraveling the Influence of Perivascular Adipose Tissue on Vascular Health View all articles

Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis -An Update on Recent Findings

Provisionally accepted
Tomoya Hara Tomoya Hara *Masataka Sata Masataka Sata
  • Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

The final, formatted version of the article will be published soon.

    Lifestyle-related diseases, such as atherosclerosis and diabetes, are now considered to be a series of diseases caused by chronic inflammation. Adipose tissue is considered to be an endocrine organ that not only plays a role in lipid storage, heat production, and buffering, but also produces physiologically active substances and is involved in chronic inflammation. Perivascular adipose tissue (PVAT) surrounding blood vessels similarly produces inflammatory and anti-inflammatory physiologically active substances that act on blood vessels either directly or via the bloodstream. Epicardial adipose tissue (EAT), which is in direct contact with the coronary arteries inside the pericardium, is thought to have a direct effect on the coronary arteries as well. The presence and inflammatory status of these adipose tissues can be evaluated by imaging tests, and has been shown to be associated with the presence of current cardiovascular disease (CVD) and to be a prognostic factor. It is also expected to become a new diagnostic and therapeutic target for CVD.

    Keywords: perivascular adipose tissue (PVAT), Epicardial adipose tissue (EAT), vasa vasorum (VV), chronic inflammation, Atherosclerosis, Cardiovascular disease (CVD)

    Received: 04 Nov 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Hara and Sata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Tomoya Hara, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

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