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REVIEW article

Front. Physiol.
Sec. Cardiac Electrophysiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1520008

Brugada Syndrome Update

Provisionally accepted
Tingting Xu Tingting Xu 1Shaokun Wang Shaokun Wang 1Jiawen Wang Jiawen Wang 2Jihong Xing Jihong Xing 1*
  • 1 Department of Emergency Medicine, First Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 2 Department of Nuclear Medicine, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Brugada syndrome (BrS) is a cardiac channel disease characterized by autosomal dominant inheritance (predominantly secondary to loss-of-function mutations in the αsubunit of the cardiac sodium channel protein Nav1.5), originally discovered and named by Josep and Pedro Brugada, whose typical symptoms are syncope, polymorphic ventricular tachycardia (PVT) or ventricular fibrillation (VF) . If these arrhythmias persist, BrS may lead to sudden cardiac death (SCD). Interestingly, the incidence of SCD is high in those patients with normal cardiac structure. Therefore, early diagnosis and identification of high-risk individuals are of paramount importance. This article reviews the understanding and development of BrS, and details the latest advances in diagnosis, risk stratification and treatment. In addition, the existing disputes are analyzed and evaluated.

    Keywords: Brugada syndrome (BrS), Right ventricular outflow tract (RVOT), Quinidine, implantable cardioverter defibrillator, Radiofrequency ablation

    Received: 30 Oct 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Xu, Wang, Wang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jihong Xing, Department of Emergency Medicine, First Hospital of China Medical University, Shenyang, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.