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BRIEF RESEARCH REPORT article

Front. Physiol.
Sec. Striated Muscle Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1508709

Association between phase angle and daily creatinine excretion changes in critically ill patients: An approach to muscle mass

Provisionally accepted
Patricio Vargas-Errázuriz Patricio Vargas-Errázuriz 1Natalia Dreyse Natalia Dreyse 2Rene Lopez Rene Lopez 1*Marcelo Cano-Cappellacci Marcelo Cano-Cappellacci 3Jerónimo Graf Jerónimo Graf 4Julia Guerrero Julia Guerrero 5
  • 1 Departamento de Paciente Crítico, Grupo Intensivo, ICIM, Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
  • 2 Departamento de Paciente Crítico, Departamento de Farmacia, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile
  • 3 Physical Exercise Sciences Laboratory, Physical Therapy Department, University of Chile, Santiago, Santiago Metropolitan Region (RM), Chile
  • 4 Departamento de Paciente Crítico Clínica Alemana de Santiago, Clínica Alemana, Universidad del Desarrollo, Santiago, Santiago Metropolitan Region (RM), Chile
  • 5 Departamento de Fisiología - Instituto Ciencias Biomédicas ICBM - Facultad de Medicina, University of Chile, Santiago, Santiago Metropolitan Region (RM), Chile

The final, formatted version of the article will be published soon.

    Assessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°), derived from bioelectrical impedance analysis (BIA), as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DCE), a structural and metabolic muscle mass marker. In 20 ICU patients, we observed a linear relationship between PA° and DCE at initial (S1) and follow-up (S2) points, with Rho values of 0.78 and 0.65, respectively, as well as between their Percentage changes (Rho = 0.80). Multivariate analysis confirmed a strong association between changes in PA° and DCE (adjusted R² of 0.73), while changes in the extracellular water to total body water (ECW/TBW) ratio showed no significant association. This study establishes the relationship between a BIA-derived independent-weight parameter and DCE, highlighting PA°'s potential for muscle mass monitoring during acute changes, such as those seen in ICU settings. Integrating PA° into clinical practice could provide a non-invasive and reliable tool to enhance muscle assessment and support targeted interventions in critically ill patients.

    Keywords: Phase Angle1, Daily Creatinine Excretion2, Critical care3, muscle mass4, Bioelectrical Impedance Analysis5

    Received: 09 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Vargas-Errázuriz, Dreyse, Lopez, Cano-Cappellacci, Graf and Guerrero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rene Lopez, Departamento de Paciente Crítico, Grupo Intensivo, ICIM, Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.